Hand foot syndrom

What is the hand-foot syndrome? Hand-foot syndrome is a relatively common form of cutaneous dysaesthesia, mainly of the palms and soles, which follows chemotherapy. It has many other names including: Palmar-plantar (palmoplantar) dysaesthesia; Acral erythema; Burgdorf syndrome; Chemotherapy-induced acral erythema; Palmar plantar erythem The following options can be used to treat hand-foot syndrome: Topical pain relievers, such as lidocaine (multiple brand names). These are used as a cream or a patch over painful... Topical moisturizing exfoliant creams are available, either over the counter or through your doctor. Those. Also called hand-foot syndrome or hand-to-foot syndrome, Palmar-Plantar Erythrodysesthesia is a side effect, which can occur with several types of chemotherapy or biologic therapy drugs used to treat cancer. For example, Capecitabine (Xeloda ® ), 5-Flurouracil (5FU), continuous-infusion doxorubicin, doxorubicin liposomal (Doxil ® ), and. Syndrom ruka-noha (syndrom palmoplantární erytrodysestézie, anglicky hand-foot syndrom) jsou kožní změny především na dlaních a chodidlech. Projevuje se sníženou citlivostí, bolestí, zarudnutím nebo otokem, méně často v těžším stupni až olupováním či mokváním kůže

Hand-foot syndrome DermNet N

What is hand-foot syndrome? Hand-foot syndrome is a reaction to a medicine used to treat cancer. Hand-foot syndrome usually affects the palms of the hands and the soles of the feet. What are the signs and symptoms of hand-foot syndrome? Signs and symptoms may range from mild to severe. Severe problems may affect your daily activities Hand-foot-and-mouth disease often causes a rash of painful, red, blister-like lesions on the soles of the feet. Hand-foot-and-mouth disease may cause all of the following signs and symptoms or just some of them. They include: Painful, red, blister-like lesions on the tongue, gums and inside of the cheeks Hand-foot syndrome (HFS) has proven to be a chronic dose-limiting toxicity of capecitabine, leading to significant morbidity in patients receiving this agent. The purpose of this review is to define the pathophysiology, risk factors, incidence and management of capecitabine-induced HFS From Wikipedia, the free encyclopedia (Redirected from Hand-foot syndrome) Chemotherapy-induced acral erythema is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer Das Hand-Fuß-Syndrom (HFS oder palmar-plantare Erythrodysästhesie, PPE) ist eine mit schmerzhafter Schwellung und Rötung einhergehende erythematöse Hautveränderung an den Handflächen und Fußsohlen, die als Begleitreaktion einer antineoplastischen Chemotherapie, im Rahmen einer Sichelzellenanämie oder unter Einnahme von MEK-Inhibitoren auftreten kann. Auch sensorische Störungen wie Kribbeln oder Taubheitsgefühl werden beobachtet

Hand-Foot Syndrome or Palmar-Plantar Erythrodysesthesia

T-DM1-related carotenoderma and hand-foot syndrome - The

Hand-Foot Syndrome - Managing Side Effects - Chemocar

Hand-foot syndrome is a potentially dose-limiting cutaneous toxicity. It is characterized by paresthesia in a sock-and-glove distribution, with varying degrees of pain, tingling, dryness, erythema,.. Hand-foot syndrome is a painful condition and the symptoms can make it easy to identify. As hand-foot syndrome progresses, blisters can start to form. The symptoms of hand-foot syndrome usually develop within the first three weeks of receiving chemotherapy. At first, the patient may feel numbness in the feet or hands Hand-foot-genital syndrome (HFGS) is a very rare multiple congenital abnormality syndrome characterized by distal limb malformations and urogenital defects. Visit the Orphanet disease page for more resources. Last updated: 1/1/2014 Hand-foot syndrome is a localized cutaneous side effect associatedwith the administration of several chemotherapeutic agents, includingthe oral fluoropyrimidine capecitabine (Xeloda). It is never life-threateningbut can develop into a painful and debilitating condition thatinterferes with patients' normal daily activities and quality of life Hand-foot syndrome (HFS), also known as palmar plantar erythrodysesthesia, is a dermatological side effect of some chemotherapy and biological therapy medications. It primarily affects the palms of the hands and soles of the feet

Everything you need to know about hand-foot syndrome. Constant moisturising is the best remedy against hand-foot syndrome. Relieve symptoms by keeping your hands and feet cool and using a gentle cream. Always consult your doctor or oncology nurse. Here you will find further advice on how to deal with hand-foot syndrome, also known as HFS Hand-foot syndrome, also called palmar-plantar erythrodysesthesia, is a skin reaction on the palms of the hands and soles of the feet.. Some chemotherapy and targeted therapy medicines can cause hand-foot syndrome. It's not caused by lifestyle or other factors. But there are things you can do to lessen the chances you will develop it

Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of enteroviruses. It typically begins with a fever and feeling generally unwell. This is followed a day or two later by flat discolored spots or bumps that may blister, on the hands, feet and mouth and occasionally buttocks and groin. Signs and symptoms normally appear 3-6 days after exposure to the virus Hand, foot, and mouth disease is often confused with foot-and-mouth disease (also called hoof-and-mouth disease), which affects cows, sheep, and pigs. Humans do not get the animal disease, and animals do not get the human disease. Visit the National Agricultural Library of the U.S. Department of Agriculture to learn more about Foot-and-Mouth.

Hand-foot syndrome in sickle cell anemia (371104006); Sickle cell dactylitis (371104006) Definition. A severe acute inflammatory response affecting the hands and feet of individuals with with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and. Hand-foot syndrome and hand-foot skin reaction are conditions that affect the skin on the palms of your hands and the soles of your feet. Some chemotherapy medications can cause these conditions. Medications That Can Cause Reactions Hand-foot syndrome The following medications may cause hand-foot syndrome. Capecitabine (Xeloda ) Doxorubicin (Adriamycin ) Fluorouracil (5-FU Hand-foot syndrome, also called palmar-plantar erythrodysesthesia, is a side effect of certain types of chemotherapy medicines, as well as other medicines used to treat cancer. It's not clear how hand-foot syndrome develops. One theory suggests that hand-foot syndrome happens when a small amount of medicine leaks out of the capillaries (small.

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Hand Foot Syndrome - What You Need to Kno

hand-foot syndrome: a painful desquamative syndrome associated with 5-fluorouracil, especially if given in a continuous administration and with cytarabine Hand foot syndrome timbul akibat dari beberapa jenis obat kemoterapi. Prinsip daripada 'hand-foot syndrome' (palmar=plantar erythrodysesthesia) adalah keadaan peradangan yang kronik (= terjadi pada kurun waktu yang lama dan terus menerus atau hilang timbul) terjadi pada telapak tangan dan kaki. Meskipun jarang, hand-foot syndrome kadang muncul di daerah lutut dan siku 그 중에서 특히 괴로움을 주는 부작용들 중 하나는 수족증후군 (hand-foot syndrome, HFS)입니다.속담에 도둑질도 손발이 잘 맞아야 한다는 말이 있는데, 요즘에는 항암치료도 손발이 잘 맞아야 편안하게 받을 수 있네요 Hand-foot syndrome (HFS) is a skin reaction on the palms of the hands and/or the soles of the feet as a result of certain chemotherapy agents. It may also be referred to as acral erythema, palmar plantar erythema (PPE), or Burgdorf reaction

Hand-foot-and-mouth disease - Symptoms and causes - Mayo


Hand foot syndrome (Palmar-plantar erythrodysaesthesia syndrome) Grade 1 : minimal skin changes or dermatitis (e.g., erythema, oedema, or hyperkeratosis) without pain Grade 2 : skin changes (e.g., peeling, blisters, bleeding, fissures, oedema, or hyperkeratosis) with pain; limiting instrumental activities of daily livin Hand-foot syndrome, also known as Palmar-Plantar Erythrodysesthesia or PPE, is a common side effect of some chemotherapy drugs used to treat breast cancer. It usually affects the palms of the hands and soles of the feet, but it may also affect other areas such as the skin on the knees or elbows

Management of hand-foot syndrome induced by capecitabin

Hand, foot, and mouth disease (HFMD) is a common infection in children that causes sores called ulcers inside or around their mouth and a rash or blisters on their hands, feet, legs, or buttocks. Hand-foot syndrome (HFS), also known as acral erythema or palmoplantar dysesthesia, is a manifestation of painful erythema and dysesthesia mostly occurring in the palms and soles. Although many chemotherapeutic agents have been shown to cause HFS, it remains an uncommon adverse cutaneous manifestation of paclitaxel INTRODUCTION. Hand, foot, and mouth disease (HFMD) is a clinical syndrome characterized by an oral enanthem and a macular, maculopapular, or vesicular rash of the hands and feet (and possibly other locations) [].HFMD is one of the most recognizable viral exanthems in children and adults [].HFMD was first described in a summer outbreak that occurred in Toronto, Canada in 1957 and was caused by. Hand-foot-genital syndrome is a rare condition that affects the development of the hands and feet, the urinary tract, and the reproductive system.People with this condition have abnormally short thumbs and first (big) toes, small fifth fingers that curve inward (clinodactyly), short feet, and fusion or delayed hardening of bones in the wrists and ankles Hand-foot-genital syndrome (HFGS) is characterized by limb malformations and urogenital defects. Mild bilateral shortening of the thumbs and great toes, caused primarily by shortening of the distal phalanx and/or the first metacarpal or metatarsal, is the most common limb malformation and results in impaired dexterity or apposition of the thumbs

Hand, foot, and mouth disease (HFMD) is a highly contagious infection. It's caused by viruses from the Enterovirus genus, most commonly the coxsackievirus.. These viruses can spread from person. Top Hand-Foot-And-Mouth Syndrome Related Articles Fever in Adults and Children Although a fever technically is any body temperature above the normal of 98.6 F (37 C), in practice, a person is usually not considered to have a significant fever until the temperature is above 100.4 F (38 C) Hand-foot syndrome or palmar-plantar erythrodysesthesia (PPE) ranges from mild redness and swelling on the palms of the hands and soles of the feet to severe and painful cracking and sores that can interfere with walking or using hands and fingers. It appears to get worse with heat and friction. Patients are told to avoid hot water and aerobic. The Udderly Smooth website was interesting too, with a specific Oncology section referring to Hand and Foot syndrome. The testimonials looked good too! There was a stockist map of the UK and I happened to find one in my old home town of Shrewsbury (in a cycle shop of all places!) so when my family ask what they can get me for Christmas, maybe I. Hand-foot syndrome occurs between age 6 months and 3 years; it is not seen after age 5 years because hematopoiesis in the small bones of the hands and feet ceases at this age. Osteomyelitis is the.

Symptoms and Diagnosis of Hand, Foot, and Mouth Disease. Symptoms of hand, foot, and mouth disease usually include fever, mouth sores, and skin rash commonly found on the hands, mouth, and/or feet. Hand, foot, and mouth disease is common in infants and children younger than 5 years old. Most children have mild symptoms for 7 to 10 days Treatment. There's no specific treatment for hand-foot-and-mouth disease. Signs and symptoms of hand-foot-and-mouth disease usually clear up in seven to 10 days. A topical oral anesthetic may help relieve the pain of mouth sores. Over-the-counter pain medications other than aspirin, such as acetaminophen (Tylenol, others) or ibuprofen (Advil. Hand-foot syndrome (palmar-plantar erythrodysesthesia) is a common adverse effect of capecitabine [83 C, 84 c, 87 c]. In a phase III, open-label, parallel, two-arm, multicenter trial of eribulin or capecitabine for the treatment of breast cancer, 546 patients were assigned to the capecitabine treatment group

ectrodactyly - Humpath

Chemotherapy-induced acral erythema - Wikipedi

Höstblåsor kallas på engelska Hand, foot and mouth disease och förväxlas därför ibland med veterinärsjukdomen mul- och klövsjuka, som orsakas av ett helt annat virus. Sjukdomen är inte anmälningspliktig. KLINIK OCH SYMTOM . Kortvarig feber 1-2 dygn och därefter: Smärta i mun och hal Hand-foot syndrome (HFS) is a common adverse effect of anti-cancer agents and is characterized by dysesthesia and tingling of the palms, fingers and soles of the feet . The condition may progress over a few days, resulting in burning pain with diffuse erythema and swelling. In severe cases, there may be scaling, blistering, erosions or.

Background Hand-foot syndrome (HFS) is a relatively frequent dermatologic toxic reaction to certain anti-cancer chemotherapies. The syndrome can evolve into a distressing condition that limits function and affects quality of life. Pyridoxine (vitamin B6) has been used empirically for the prevention of HFS caused by anti-cancer therapy. However, evidence of its efficacy remains controversial Hand-foot syndrome (HFS), also known as palmar-plantar erythrodysaesthesia (PPE), is a common side effect associated with a number of chemotherapeutic drugs including capecitabine, fluorouracil, liposomal doxorubicin and cytarabine. A similar reaction, hand-foot skin reaction.

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Hand-Fuß-Syndrom - Wikipedi

Hand-foot syndrome (hand-foot skin reaction, palmar-plantar erythrodysesthesia): focus on sorafenib and sunitinib. Oncology 2009; 77:257. Lacouture ME, Wu S, Robert C, et al. Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib Hand-foot syndrome. is a reaction to a medicine used to treat cancer. Hand-foot syndrome usually affects the palms of the hands and the soles of the feet. Signs and symptoms. may range from mild to severe. Severe problems may affect your daily activities. Red skin that looks like a sunburn, blisters, or peeling ski 本サイトは中外製薬が運営する医療関係者向けサイトです。ゼローダ錠300の副作用手足症候群(Hand-foot syndrome)について。発現機序、発現頻度、発現時期、対処法、リスク因子、観察項目など Media in category Hand-foot syndrome The following 6 files are in this category, out of 6 total. Hand-foot Syndrome.jpg. Syndrome Main Pied 1.jpg. Syndrome Main Pied 2.jpg. Syndrome Main Pied 3.jpg. Syndrome Main Pied 4.jpg. Syndrome Main Pied 5.jpg. Retrieved from https:. Mar 25, 2021 - Explore Jennifer Gandee-Barker's board Hand foot syndrome, followed by 126 people on Pinterest. See more ideas about hand foot syndrome, foot remedies, feet care

What is hand-foot syndrome (Palmar-plantar

(Hand-Foot Syndrome) What is palmar-plantar erythrodysesthesia? Palmar-plantar erythrodysesthesia is a side effect of some cancer treatments, such as chemotherapy and targeted therapy. It is also called hand-foot syndrome. Palmar-plantar erythrodysesthesia causes redness, swelling, and pain on the palms of the hands and the soles of the feet Hand-foot syndrome is a side effect of some types of chemotherapy. Hand-foot syndrome happens when a small amount of the drug in tiny blood vessels leaks into the surrounding skin. There are many drugs that can cause hand-foot syndrome. Some examples include

The hand-foot syndrome refers to painful redness (erythema) and swelling of the palms of the hands and soles of the feet, which can occur as a side effect of chemotherapy with cytostatic drugs. CAUSES. The exact pathogenesis of the hand-foot syndrome is unclear. The most common form of hand-foot syndrome is associated with the administration of. Onemocnění ruka-noha-ústa (Hand, Foot, and Mouth Disease - HFMD) Zprávy EM (SZÚ, Praha) 2012; 21 (6-7): 241-242. Celý článek 18. červen 2015 | Kateřina Fabiánová, Petra Rainetová. Nahoru Hand-foot syndrome is a side effect of some chemotherapy drugs that results when a small amount of drug leaks out of the smallest blood vessels in the palms of the hands and soles of the feet. The amount of drug in the capillaries of the hands and feet increases due to the friction and subsequent heat that is generated in those extremities Klíčová slova: syndrom ruka-noha-ústa, exantémová onemocnění, enteroviry, Coxsackie viry. Hand-foot-mouth disease The article deals with the hand, foot and mouth disease. In addition to the issues of common symptoms and management of this di sease, it focuses on possible severe neurological complications Split hand foot malformation (SHFM) is a type of birth defect that consists of missing digits (fingers and/or toes), a deep cleft down the center of the hand or foot, and fusion of remaining digits. The severity of this condition varies widely among affected individuals. SHFM is sometimes called ectrodactyly; however, this is a nonspecific term used to describe missing digits. SHFM may occur.

How to Use Essential Oils for Hand, Foot and Mouth Disease

Hand-Foot Syndrome and Hand-Foot Skin Reaction Memorial

  1. Hand-foot skin reaction (HFSR), also known as hand-foot syndrome or palmar-plantar erythrodysesthesia (PPE), is an adverse effect of several chemotherapeutic agents. The syndrome is characterized by redness, swelling, pain, and tingling in the palms of the hands and the soles of the feet
  2. There are bar and pie charts that show hand-foot syndrome over the first 24 weeks of treatment. This is the profile page for the patient-reported symptom of hand-foot syndrome from AURA3
  3. Hand foot syndrome otherwise known as Palmer-Planter erythema is a condition which can occur with some chemotherapy and biological agents.The severity of the condition depends on: The type of drug used; The dose used; How many cycles have been given; The inherent sensitivity of the recipien
  4. hand-foot syndrome Hand-Foot syndrome: Hand-Foot Syndrome, which is also known as Palmar-Plantar Erythrodysesthesia - PPE, is a side effect, which can occur with some chemotherapy. For example, Capecitabine (Xeloda®), 5-Fluorouracil (5FU), continuous-infusion of Doxorubicin, Liposomal Doxorubicin (Caelyx®), Sunitinib (Sutent®) and.
  5. Purpose: The purpose of this study was to describe adherence to self-care for hand-foot syndrome (HFS) and the relationship between self-care and health-related quality of life (QOL). Methods: A cross-sectional study was conducted on 105 consecutive outpatients with HFS. To assess self-care for HFS and QOL, the participants were asked to complete self-care and HFS-14 (hand-foot syndrome.
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Hand-Foot Skin Reaction Multikinase Inhibitor Skin Toxicit

  1. istration of 5-FU or its orally applicable prodrug capecitabine. Its severity can even lead to interruption of the otherwise effective anticancer therapy
  2. Lassere Y, Hoff P: Management of hand-foot syndrome in patients treated with capecitabine (Xeloda). Eur J Oncol Nurs 8:S31-S40, 2004 (suppl 1) 8. Erber R, Thurnher A, Katsen AD, et al: Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
  3. Hand-foot syndrome (HFS), also known as palmar-plantar Erythrodysesthesia (PPE), acral erythema or Burgdorf reaction, is a dermatologic toxic reaction to certain chemotherapies, including sorafenib. A high incidence of adverse events is already described in dermatological clinical trials of this drug, but its use in medical practice, common in the patient with metastatic thyroid carcinoma has.

hand-foot syndrome a syndrome of erythema and dysesthesias of touch in the palms and soles, followed by desquamation; seen as a reaction to certain chemotherapeutic agents. Called also acral, palmar-plantar, or palmoplantar erythrodysesthesia and acral, palmar-plantar, or palmoplantar erythrodysesthesia an Hand-Foot Syndrome (HFS) Updated. Background. Hand-foot syndrome (HFS), also called palmar-plantar erythrodysesthesia (PPE), is a cutaneous complication associated with continuous fluorouracil therapy, oral capecitabine, and liposomal doxorubicin. First reported in 1974, this complication was noted in patients receiving antimetabolites and some. Background Hand-foot syndrome (HFS) is a relatively common dermatologic toxic reaction to certain anticancer therapies.Although not life-threatening, this complication can reduce patient quality of life. Dose modification of the inciting agent serves as the most effective management of HFS, although a variety of anecdotal reports suggest that other agents may also be efficacious Hand-foot syndrome is a side effect of some chemotherapy drugs that results when a small amount of drug leaks out of the blood vessels, damaging tissues. This tends to happen in the hands and the feet because of the increased friction and heat that your extremities are exposed to through daily activities

Hand Foot Syndrome - an overview ScienceDirect Topic

Patients who have been receiving oral Xeloda for at least 5 days will be randomized to receive prophylactic treatment with either placebo, topical corticosteroids or Bepantol. The anticipated time on study treatment is until disease progression or development of hand-foot syndrome, and the target sample size is 500+ individuals Hand, Foot and Mouth Syndrome (HFM) is primarily a common childhood illness. However, adults can get it too. HFM is caused by an enterovirus. Persons may develop the disease when they make direct contact with the saliva, blister fluid or stool of an infected person. Persons with HFM are most contagious during the first week of th Hand-foot Syndrome. Infarction of small tubular bones in hands and/or feet in early childhood sickle cell anemia Hand, foot and mouth disease is a common infection that causes mouth ulcers and spots on the hands and feet. It's most common in young children - particularly those under 10 - but can affect older children and adults as well. Hand, foot and mouth disease can be unpleasant, but it will usually clear up by itself within 7 to 10 days

Prevention and management of hand-foot syndromes

  1. Hand-foot syndrome (HFS) is a rare erythematous skin lesion of the palmoplantar areas of hands and feet. Some authors use the term acral erythema or erythrodysaesthesia because of the painful erythema on the palms and soles (1). HFS was initially reported in association with acute crisis in sickle cell anaemia and thalassaemia and, more.
  2. For those of you who do not have this issue, hand foot syndrome causes redness, pain and swelling in the palms of the hands and soles of the feet. Neuropathy causes sharp, jolting pains in the hands and feet, along with taking away much of the feeling. My fingertips are basically gone with pain as well. The foot part started in my toes, but.
  3. Hand, foot and mouth disease is a common but highly contagious infection in children caused by enteroviruses, including coxsackieviruses. While generally a mild illness, some children will have fever, sore throat and tiredness and blisters which can be uncomfortable. It mainly occurs in children under 10 years of age but can also occur in older.
  4. Correlations between development of hand-foot syndrome (HFS) and efficacy in patients receiving capecitabine (CAP)-containing therapy are reported in the literature. We explored the relationship.
  5. hand foot syndrome pictures. A 44-year-old member asked: are there any long term effects from taking xeloda (capecitabine) for hand foot syndrome? Dr. Ed Kaplan answered. 39 years experience Hematology and Oncology

What is Hand-Foot Syndrome? (with pictures

  1. Importance Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment.. Objective To compare the incidence and time to onset of grade 2 or greater HFS in patients receiving pyridoxine vs placebo and to identify biomarkers predictive of HFS.. Design, Setting, and Participants This single-center, randomized double-blind, placebo-controlled phase 3 trial conducted at National.
  2. T1 - Hand-foot syndrome variant in a dihydropyrimidine dehydrogenase - Deficient patient treated with capecitabine. AU - Saif, Muhammad Wasif. AU - Elfiky, Aymen. AU - Diasio, Robert. PY - 2006/9. Y1 - 2006/9. N2 - We present a case with dihydropyrimidine dehydrogenase (DPD) deficiency that manifested a variant of hand-foot syndrome (HFS)
  3. Hand-Foot Syndrome/Palmar-Plantar Erythrodysesthesia Syndrome Overview Palmar-plantar erythrodysesthesia (PPE), also called a hand-foot syndrome, is a relatively common dermatologic toxic reaction associated with cytotoxic chemotherapy that can limit the use of such drugs
  4. Subsequently, many reports, using different terms for the condition (acral erythema, hand-foot syndrome, palmar-plantar erythema, Burgdorf's reaction, and toxic erythema of the palms and soles), have appeared in the literature. Many drugs have been implicated as causing PPE
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{{configCtrl2.info.metaDescription}} space of the foot, and injury to the superficial peroneal nerve, which leads to sensory changes at skin over the anterolateral aspect of the leg and the dorsum of the foot (except for forearm compartment syndrome increases with a concomitant injury of the ipsilateral elbow . On the other hand, in children, distal humerus fractures and concomitant. Hand, foot, and mouth disease (HFMD) is an acute viral illness characterized by vesicular eruptions in the mouth and papulovesicular lesions of the distal limbs. It should not be confused with foot and mouth disease of animals, which is caused by a different virus. HFMD is usually mild and self-limiting Hand-Foot Syndrome: Chemotherapy-induced dermal side effects that are associated with the use of various CYTOSTATIC AGENTS. Symptoms range from mild ERYTHEMA and/or PARESTHESIA to severe ulcerative dermatitis with debilitating pain involving typically palmoplantar and intertriginous areas This is a drug taken orally that is converted into 5-FU, which is the chemo drug that most of us received. Since I had 5-FU, I'm not familiar with it or hand & foot syndrome. I was burned not only in the anal area but also my inner thighs. There are various topical things that can be prescribed for you to ease the pain from the burns